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8 The body requires a delicate balance between production and detoxification/transport of harmful reactive species and protein adducts, and when these defenses are overwhelmed at hepatotoxic doses of APAP, the glucoronidation and sulfonation pathways become saturated, pushing the majority of APAP to be metabolized to NAPQI by the CYP 2E1 pathway and resulting in GSH depletion and build-up of toxic NAPQI

10.1172/JCI10588 50 HongJ.-Y.ChungH.-J.LeeH.-J.ParkH

These changes will allow hospital systems and private practices to use sophisticated biopsy methods with higher reimbursement rates than in previous years

Hu GY, Kornblau SM , Zhang W, Deisseroth AB
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