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in NP-MSCs, the combined effect of hypoxia and nutrient deprivation inhibits cell proliferation, induces apoptosis, enhances caspase-3 activity, and downregulates functional genes (e.g., proteoglycan, collagen-I and -II) and stem cell-related genes (including Oct4, Nanog, Jagged, and Notch1) (Tian et al., 2020)

The word eicosanoid arises from the Greek root meaning twenty, and the term classically refers to unbranched 20-carbon molecules derived from arachidonic acid oxygenation

In homozygous human FcRn Tg32 mice, groups of female and male mice (816 weeks, 21.530.0 g, 5 mice/23 cages/group) were given either IV or SC injection, into the scruff of the neck, of 4 mg/kg of GLP-1 albumin fusions, diluted in DPBS (pH 7.4) (Sigma-Aldrich), respectively

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Other peptides function much like hormones, acting at cell-surface receptors, while others enter cells and bind to intracellular proteins