igf-1 lr3 effects on sleep and IGFBP-3 in Inflammatory Cachexia Recombinant Human LR3 IGF-I/IGF-1 Protein,
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AntunesKHFachiJLde PaulaRda SilvaEFPralLPdos SantosAet al

The indirect effects via SHBG would still be the primary mechanism to observe