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The use of fluorescence resonance energy transfer-based biosensors of various GPCRs indicated the formation of distinct ligand-specific receptor conformations (Kim et al., 2022), and recent technical advances have revealed a far wider and more dynamic range of receptor and -Arr conformations that are ligand and receptor specific (Lee et al., 2016

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This is because NNMTi improves fat metabolism to assist weight loss, alleviates intestinal inflammation, and reduces gastrointestinal adverse reactions.These combined intervention studies provide novel strategies for clinical obesity management and expand the application scope of NNMTi