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Vitamin B 9 (folate) is involved in the biosynthesis of nucleic acids, protein, blood cells, and the nervous system tissues [31], while B 12 (cobalamin) is involved in DNA synthesis as well as fatty acid and amino acid metabolism [32]

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The physical work capacity until fatigue was increased by 17% in the Pycnogenol group compared to placebo

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Figure 4 The first clear evidence that in addition to GHRH and SS, another factor had to be involved in the regulation of GH secretion came from several studies in humans in which it was shown that the nocturnal increase in GH was not inhibited by the infusion of octreotide, an analog of SS ( There is a possibility that ghrelin interacts with GHRH at the hypothalamic level, since it has been shown that transgenic rats that have a decreased expression of the ghrelin receptor GHSR-1a in the arcuate nucleus of the hypothalamus, where GHRH is produced, show a decrease of GHRH in the neurons that produce it ( Figure 4A )