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Description
Influence of Melatonin Treatment on Cellular Mechanisms of Redox Adaptation in K562 Erythroleukemic Cells
CoQ is synthesized by at least 12 proteins that form a multiprotein complex in the mitochondria, and the pathogenesis of CoQ10 deficiency involves deficient ATP production and excessive ROS formation in humans
These are mediated by 11-hydroxylase (P450c11 or CYP11B1), which generates cortisol (followed by activities of the ER enzymes P450c21 and P450c17), and aldosterone synthase (P450c11AS or CYP11B2) which produces aldosterone 91,92,93,94
It is believed to complex with carrier proteins or exist as part of a prohormone molecule in vivo, but the structure or gene of such a precursor has not been discovered so far
PMID 10360940
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