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As a product of the NNMT enzymatic reaction, MNA is a natural inhibitor of NNMT

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Keremi B, Lohinai Z, Komora P, Duhaj S, Borsi K, Jobbagy-Ovari G, et al

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Biol Psychiatry 81: 848861

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The answer is because if the reason they are deficient is that they cannot absorb B12 from diet , then giving them supplements that need absorbing in the gut is not going to work well

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It can cause permanent neurological changes or fatigue

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