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MiR-200a is involved in regulating redox imbalance, and the suppression of aortic endothelial miR-200a expression under hyperglycaemic conditions increases the expression of kelch-like ECH-associated protein 1 (Keap1), which is linked to Nrf2 binding and leads to the inactivation of Nrf2 antioxidant signalling, thereby inducing diabetic vascular endothelial dysfunction [91]

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A metaanalysis revealed that CSF syn levels were markedly reduced in individuals with PD compared with controls, with seed amplification assays demonstrating a sensitivity of 88% and specificity of 95% [247]

Here, we show that a major mechanism by which PAHSAs protect islets of the NOD mice is by directly preventing and reversing the initial steps of metabolic stress-induced senescence

The content of Cd and CB in IPF lung tissue increased significantly and was directly proportional to the amounts of citrullinated vimentin (Cit-Vim)

Furthermore, all human sample collections were conducted in accordance with the approval of the Institutional Research Ethics Committee