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demonstrated that netrin-1 expressed macrophages could upregulate PPAR expression by activating the unc-5 netrin receptor B (UNC5b) receptor to promoted autophagy through increasing LC3 conversion, p62 degradation, and autophagosome formation, suppressing hepatic steatosis in HFD-induced MASLD mice model [21]

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Schulze MB, Martinez-Gonzalez MA, Fung TT, Lichtenstein AH, Forouhi NG