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As intracellular GSH is exhausted, the GSH synthesis system will be activated accordingly, which would weaken the efficacy of GSH exhaustion-based cancer therapies in long-term treatment (Niu et al., 2021)

Abbreviations AAT aspartate aminotransferase Ala alanine ALAT alanine aminotransferase APOE apolipoprotein E Asp aspartate BCAA branchedchain amino acid BCAT branchedchain amino acid aminotransferase BCKA branchedchain keto acid CaMKII Ca 2+ /calmodulindependent protein kinase II alpha EAAT excitatory amino acid transporter GABA aminobutyric acid GABAT GABA transaminase GAD glutamate decarboxylase GAT GABA transporter GDH glutamate dehydrogenase GHB hydroxybutyrate GLAST glutamate aspartate transporter 1 GLT1 glutamate transporter1 Glu glutamate GS glutamine synthetase iPSC induced pluripotent stem cell LAT Ltype amino acid transporter MAS malateaspartate shuttle NMR nuclear magnetic resonance OAA oxaloacetate PAG phosphateactivated glutaminase PC pyruvate carboxylase PDH pyruvate dehydrogenase Pyr pyruvate ROS reactive oxygen species SLC solute carrier SNAT sodiumcoupled neutral amino acid transporter SSADH succinic semialdehyde dehydrogenase TCA tricarboxylic acid (cycle) KG ketoglutarate 1

Urine testing: This can measure metabolites of mold toxins and glutathione levels, the latter of which can be depleted due to mold exposure

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The desire to remove associated aversive symptoms/stimuli, or to re-live memories of a previous positive experience, with the former tending to predominate over the latter, leads to drug/alcohol seeking and taking with the recruitment of both habit- and cognitive-memory circuits, again with the former predominating over the latter in late stage dependence

Strikingly, this oxidizing shift in the [NAD + ]/[NADH] induced by ketone ester treatment and the oxidizing shift in the total NAD + /NADH during a ketogenic diet were opposite to the reductive shifts that occurred in the hippocampus and cortex during fasting, as discussed above