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Beyond serving as a risk factor, T2DM has been shown to worsen disease progression and increase symptom severity in PD [65]

doi: 10.1016/j.phrs.2019.104462, PMID: [DOI] [PubMed] [Google Scholar] 70.Zhou L, Xiong JY, Chai YQ, Huang L, Tang ZY, Zhang XF, et al

In mice and rats, three distinct GPx4 isoforms, cytosolic GPx4, mitochondrial GPx4 (mGPx4), and nuclear GPx4 (nGPx4), were identified with different functions

The reviewer RH declared a past co-authorship with the author AI to the handling editor

In the same vein, it has been reported that ablation of Gpx4 in HSCs triggers anemia associated with an increase in the fraction of erythroid precursor cells and reticulocytes

The findings may not be generalizable to populations where viral hepatitis, autoimmune hepatitis, or cholestatic liver disease predominate, or to healthcare settings with different standard-of-care protocols, alcohol consumption patterns, or nutritional backgrounds