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They were probably related

Tudhope GR, Swan HT, Spray GH

All statistical analyses were performed using Graphpad Prism 7.0 with an experiment-wise error rate of = 0.05
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For others, it can take longer, especially if symptoms have been present for months or if there are multiple contributing factors (iron, vitamin D, thyroid issues, sleep, stress, etc.)

skin flushing is far less common with nicotinamide than with niacin (nicotinic acid)
