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Introduction For more than 20 years, surgically implanted vagus nerve stimulation (VNS) has been recognized as an adjuvant neuromodulation therapy for epilepsy ( nucleus tractus solitarius and locus coeruleus are believed to be the primary targets of VNS, although the precise mechanisms are still mostly unknown ( The most widespread and second most common neurodegenerative movement disorder, PD is characterized by bradykinesia, resting tremor, rigidity, and postural instability ( It has recently been reported that VNS can improve mobility in a rat model of PD ( locus coeruleus ( We investigated the effectiveness of cervical nVNS (gammaCore, ElectroCore, Inc., NJ, United States) as an addition to standard treatment for PD patients with FOG in a randomized double-blind sham-controlled cross-over trial