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7.4.3 Multi-target cocktail approach Current therapeutic strategies for AD prioritize pharmacotherapy supplemented by rehabilitative training, as single-target or monotherapeutic approaches yield largely unsatisfactory outcomes, establishing multitarget combination therapies (cocktail therapy) as the emerging mainstream paradigm

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Acknowledgements We thank Karin Schlegelmilch for constructive discussions and advice on YAP1, Steve Hooper for cloning and Erik Sahai for providing the pBabe YAP1 5SA-YFP plasmid, all members of the Department of Translational Genomics for constructive feedback, Henning Walczak and Manolis Pasparakis for providing recombinant TRAIL and TNF, respectively, Johannes Khle for providing buffy coats and Trudy Oliver for advice

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