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demonstrated that ZVI-NPs degrade NRF2 and promote ferroptosis while reprogramming the TME to strengthen immunity against tumors (Hsieh et al

GPX3 is not characteristic in transcriptional regulation, and the upregulation of GPX3 expression under inflammatory conditions is thought to be due to oxidative stress

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Noctor and Foyer, 1998)

Cancer history or active malignancy concerns need clinician review before GH-axis stimulation is considered

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