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Specific SNPs and haplotypes in the HLA region, such as HLA-DPA1 01:03-DPB1 04:01 (HLA-DP401) and HLA-DPA1 01:03-DPB1 03:01 (HLA-DP301), were associated with increased risk and potential protection, respectively [29]

Researchers should document baseline measurements before starting a protocol, track relevant metrics at regular intervals, and note any side effects or unexpected responses

Acknowledgements This study was partially supported by (1) Grant-in-Aid for Scientific Research (C) of the Ministry of Culture and Science of Japan (20590810, 23591017, 24591020, 12008507, 17877850, 17K09468, 15K09052, 24591020, 15K09052, 18K0792, 121K07943), (2) the Research Program on Intractable Diseases, from the Ministry of Labor and Welfare of Japan, and (3) grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan, (4) the Research Program from the Japan Medical Research and Development (AMED) (17824893), and (5) The branding program as a world-leading research university on intractable immune and allergic diseases supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan

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knocking down ELAVL1 alone noticeably decreased proliferation, migration, and invasion, but combining ELAVL1 and GAC knockdown (which depleted both glutaminase isoforms) did provide a small further decrease in cell growth, migration and invasion compared to that with ELAVL1 knockdown alone