glutathione iron chelation Revisiting the role of in ferroptosis Therapeutic potential of iron chelators

Pflugers Arch 472: 9911002, 2020

These results may explain the ineffectiveness of the 10 M dose of LA treatment, as the increased formation of peptide fragments (particularly LA fragment 2) may share enough similarities to the Zot and zonulin receptor-binding motif (G XXX VQ X G) to competitively inhibit LA binding to EGFR and/or PAR2

This molecular mimicry can initiate and perpetuate autoimmune attacks on thyroid tissue, contributing to the progression of HT (Crotty, 2014)

To data, intensive efforts have been made to clarify the functional role of ZO proteins, but it has been difficult to obtain clear evidence showing the importance of ZO proteins in TJ regulation

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3) exhaustion stemming from chronic exposure to tumor antigen