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The authors concluded that both RVCDOX and RSDOX delivered a higher concentration of DOX to cytoplasm which led to better efficacy for tumor inhibition in c57BL/6 mice tumor models compared to disulfide containing RSSDOX
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At the same time, metabolic shift towards aerobic glycolysis, altered lipid metabolism, and glutamine dependency due to oncogenic signaling and hypoxic stress, further promotes tumor survival and therapy resistance (123)
Mov Disord 24:979983 Mischley LK, Lau RC, Shankland EG, Wilbur TK, Padowski JM (2017) Phase IIb study of intranasal glutathione in Parkinson's disease
