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The Human Research Gap No clinical trials have ever been conducted on the unmodified fragment

However, it is noteworthy that ten oligonucleotide drugs have been officially approved by FDA as of January 2020 [55], which means that the technological obstacles for oligonucleotide therapeutics are being solved step by step and the development of oligonucleotide drugs targeting NNMT is still a promising method for the prevention or treatment of obesity and related T2D in the future

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References: Misra M

Human trials mainly report safety/tolerability, with inconsistent weight outcomes