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These inflammatory cytokines and second messenger signaling molecules each contributes to metabolic and reproductive disturbances, including insulin resistance and obesity (zdemir Baer et al., 2022

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However, deficiency in either SMARCA4, SMARCB1 or PBRM1 attenuates recruitment of these transcription factors, thereby repressing expression of SLC7A11 , which then reduces transport of cystine into cells