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We don't know," Priest said, adding, "We don't know why infants have congenital heart disease to begin with." Saha said further research into why congenital heart disease leads to adult heart problems could help shape follow-up care

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Thus, in a nutshell, it is possible that the initial DNA damage that predisposes melanocytes to malignant transformation and cytogenetic alterations that later promote actual malignant transformation of the initially transformed melanocytes may be driven by dysregulation in melanin biosynthesis and by the increased cellular content of melanin [10]