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While only a limited number of cases have been identified since the initial report, 22 this unique entity has recently come to the forefront, since the group of Dianna Milewicz 37 has identified mutations in YY1AP1 at the origin of the disease

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Pain relief and improved function One study revealed that 69% of patients who received mesenchymal stem cells for lumbar disc degeneration experienced a 50% decrease in pain