glutathione effect on dopamine Alanine and targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects a blood–brain barrier model | Fluids and Barriers of the CNS Impaired striatal glutathione–ascorbate metabolism induces

N-acetylcysteine (NAC), a well-known antioxidant, could attenuate cognitive behavioral impairments and neuroinflammatory damage by restoring inflammatory and neurodevelopmental mediators

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Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition