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Inflammatory stimuli upregulate the expression levels of indoleamine 2,3-dioxygenase, which converts tryptophan to immunosuppressive kynurenine metabolites, thereby suppressing pro-inflammatory responses and promoting regulatory T cell proliferation 11

The conservative approach is to continue using the vial but be aware that effectiveness may be reduced

Jia et al., 2016

Many clients describe the sensation as similar to a regular vaccination

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Frischknecht L