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Oxidative stress, in particularly in post-prandial state, plays a vital role in the pathogenesis of the diabetic complications

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Preclinical research refers to early-stage studies conducted in laboratory settings using cell cultures or animal modelscommonly rodentsto explore biological mechanisms and generate hypotheses

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Hypotheses and objectives were clearly described in 69% of the studies

This was later explained by treatment with the antioxidant N-acetylcysteine, which resulted in the exposure of circulating melanomas to significantly greater levels of oxidative stress than did subcutaneous tumors