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10.1016/j.bprint.2021.e00165 91 LockeD

Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis

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Developed in the laboratory of Joseph Harding at Washington State University as part of a program optimizing angiotensin-IV-derived neurotrophic peptides, Dihexa is approximately seven orders of magnitude (~10,000,000-fold) more potent than BDNF in inducing functional synaptogenesis between hippocampal neurons in vitro a figure that, even discounted aggressively, places it in a category of its own

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so it must be biosynthesized from its constituent amino acids, cysteine, glycine, and glutamic acid