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Although approved for use as a general anesthetic, ketamine has recently attracted interest for its effects in psychiatric disturbances, including substance use, depression, and anxiety disorders

What they found: Mean weight loss: 2.6 kg vs 2.3 kg placebo , a difference of only 0.3 kg (1 %) Statistically non-significant Clinically unsatisfactory for the obesity indication Safety profile remained favorable Why it matters: The study stopped the development of AOD-9604 as a drug

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NNMT sits between NAD+ metabolism and one-carbon methylation metabolism, pathways that support redox reactions, DNA repair, and transcriptional regulation

Another benefit of this shot has been linked to a decline in brain function, depression, and osteoporosis