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Nrf2-ARE pathway In vitiligo, inactive Nrf2 signaling is ineffective in protecting HEM from H 2 O 2 -induced OS damage and, therefore, rarely prevents melanocyte apoptosis by mediating its downstream antioxidant gene heme oxygenase-1 (HO-1) (120)

We then investigated whether this protective effect was due to increased intracellular GSH levels

While protein disulfide exchange with a thiol can be catalyzed by PDI, some proteins contain a microenvironment in which thiolate (S ), which is far more reactive than is a thiol in both reaction with H 2 O 2 or disulfide exchange, is formed

Along with matrix effects and multiple variable experimental conditions, performing the assays (radical generator, time of measure, expression of results, etc.) makes it difficult to compare the reported data

There is growing interest in promoting the consumption of lignan-rich foods in human diets