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doi: 10.1155/2012/835059

Hypotheses 2 , 359362 (2009)

K.MadanJ.et al (2022)

Insulin-like growth factor (IGF) system in liver diseases

Because lactate exerts immune-suppressive effects on T cells 40 , we asked whether blockade of lactate transporter MCT1 induces changes in metabolic and tolerogenic immune phenotype of DC
However, in the SW620/Ad300 (P-gp-overexpressing) and S1-M1-80 (ABCG2-overexpressing) colon cancer xenograft models, the combination of regorafenib and paclitaxel or the combination of regorafenib and topotecan resulted in a synergistic antitumor effect which demonstrated that regorafenib overcame the resistance of paclitaxel to P-gp-overexpressing SW620/Ad300 tumors and the resistance of topotecan to ABCG2-overexpressing S1-M1-80 tumors in mice (Wang et al., 2017b
