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The clinical use of furosemide and ethacrynic acid
Nguyen D, Diamond LW, Cherubino P, Koala WB, Imbert M, Andreeff M
Cell 82, 14771491
However, only NQO1 has been widely investigated and will be highlighted throughout the narration
GPx7 is located within the lumen of the endoplasmic reticulum (ER), whereas human GPx8, which is anchored to the ER, functions as a type II transmembrane protein
Inhibition of Mn-SOD permits increases superoxide anion concentrations, consuming GSH reserves and thus increasing oxidative stress that feeds back to amplify TNF- activity
