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Its conjugate with paclitaxel (ANG1005 or GRN1005) [337] showed good tolerance in Phase I clinical trials [118,119] and tested for the treatment with recurrent high-grade glioma in combination with bevacizumab (NCT01480583)

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More recently a parenchymal unit in the liver has been described as a cone-shaped three-dimensional structure comprised of approximately fourteen hepatic lobules supplied and drained by common vascular tributaries (Malarkey et al

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