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10.1128/mBio.02073-17 mBio 18 DrenbergC

doi: 10.1371/journal.pgen.1009530, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 4

Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regions

M., Ropper, A

They exhibit a multifaceted mechanism of action, addressing oxidative stress, neurotransmitter imbalances, and neuroinflammation through Nf-B inhibition, replenishing GSH reserves, and alleviating the impairment of mGluR2 and mGluR3 [136, 205], acting on inflammatory state, lowering serum inflammatory cytokines and markers (IL-6, TNF-alfa, PCR) [161]
