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Malik VS, Popkin BM, Bray GA, Despres JP, Willett WC, Hu FB

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K.Shekh-AhmadT

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Often depleted by birth control pills

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UribarriJPeppaMCaiWGoldbergTLuMHeCet al

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The safety of alpha-lipoic acid use during pregnancy has not been firmly established, and ALA should be used in pregnancy only with extreme caution if at all

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This may be attributed to the role of metformin in reducing the production of sFlt-1 and soluble endoglin by endothelial cells, trophoblasts, and syncytiotrophoblasts, and modulating anti-angiogenic factors at the mitochondrial level (Romero et al., 2017)

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