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In this case, it is hypothesized that Lyme disease triggered the polyarthritis in susceptible individuals, such as those with a history of psoriasis, but that it is not due to active infection of the joint

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mice Male Sprague-Dawley rats (250+ g) were obtained from Harlan Laboratories (CA, USA) and allowed food (Harlan Teklad rodent diet) and water ad libitum in our animal facility

In Phase 1 and 2a clinical trials, once-daily subcutaneous injections of RG7697 (0.252.5 mg) for 14 days in 56 patients with T2DM and 1.8 mg of RG7697 for 12 weeks in patients with T2DM who were poorly responsive to metformin reduced body weight and improved glycemic control

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