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C.HohensteinerS.BeckerF.JoergV.et al
doi: 10.1002/ar.22689

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however, species-specific differences may limit translation, and studies using fully humanized BBB models are needed to improve clinical relevance (Guerrero et al., 2026)

Evidence has shown that the genetic polymorphism of cystathionine synthase (CBS) T833C , an enzyme involved in HHCys, was associated with an increased risk for developing stroke ( Recently, a meta-analysis study demonstrated the efficacy of folic acid supplementation in stroke prevention, also combined with statins therapy
