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Eur J Endocrinol

While the NIH does not specify a tolerable upper intake level for vitamin B12, a study published in the JAMA Network Open found that high intakes of vitamin B12, such as from daily supplementation of 25 micrograms or higher, increased the risk of bone fracture [3] [4]

The fragment works best when administered in a fasted state, as insulin can blunt its lipolytic activity

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Others who may be more susceptible to vitamin B12 deficiency are patients diagnosed with Crohns disease or celiac disease, and those who have undergone intestinal procedures such as weight loss surgery