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[8] Regulation of acid-base balance in the kidney by producing ammonium [9] Cellular energy, as a source, next to glucose [10] Nitrogen donation for many anabolic processes, including the synthesis of purines [7] Carbon donation, as a source, refilling the citric acid cycle [11] Nontoxic transporter of ammonia in the blood circulation

Gastroenterology 1985;89:1070-1077

Saha et al

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Penicillamine in Wilsons disease

110 A originates from the processing of the APP, a transmembrane glycoprotein, through its sequential cleavage by -secretase and -secretase (a multiprotein complex with PS1 or PS2 as catalytic subunits)