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Each approach is tailored to individual skin types, medical history, and the underlying mechanism driving pigment irregularity whether dullness, sun damage, or deeper dermal melanin deposits

Primary prevention focuses on mitigating risk factors at the population level to reduce disease incidence, whereas secondary prevention aims to intervene in early disease stages to slow pathological progression

In the initial step of the lipid peroxidation process, bis-allylic hydrogens (H 2 C = CH 2 ) of unsaturated lipids (RH) react with hydroxyl radicals acting as promoters of radical chain reactions

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NADH:ubiquinone oxidoreductase Complex I catalyzes the two-electron oxidation of NADH and reduction of ubiquinone to ubiquinol which is coupled to the translocation of ~4 H + to the P-side of the MIM (Verkhovskaya and Bloch, 2013)