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Int J Orthop Sci

Effects were defined as: Total Effect (TE) (XY), Direct Effect (DE) (XY unmediated), and Indirect Effect (IE) (XMY)

This enzyme requires the FAD coenzyme form of riboflavin for this reduction reaction, thus, emphasizing the role of riboflavin in the formation of reduced, active, glutathione ( Second, it has been shown that the oxidation of dihydroriboflavin, the reduced riboflavin, forming oxidized riboflavin can deactivate lipid peroxides, emphasizing the independent antioxidant property of riboflavin ( Third, riboflavin effects on antioxidant enzymes activities, including superoxide dismutase (SOD) ( Important to note, UV-B irradiation, the atmospherically predominant UV radiation, has been shown to reduce the neuroprotective effects of riboflavin both in vitro and in vivo

Abcam, ab126224, RRID:AB_11129511), POLD1 (1:1000

The gray quantitative data of western blotting was determined by image J software

The potential applications of PCS in combating multiple stresses are also discussed