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Overall Evidence for the Use of B12 for Painful Peripheral Polyneuropathy Taking into account the above evidence, there is level III evidence overall to support the use of B12 either as monotherapy or as a combination therapy for treating neuropathic pain caused by peripheral polyneuropathy

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Finally, the authors demonstrated that chicoric acid improved mitochondrial dynamics and mitophagy to alleviate mitochondrial damage in renal tubular epithelial cells in HFD-induced CKD mice [177]