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In contrast, SLC25A40 lacks the GSH-sensing cysteines of SLC25A39 and, as independently shown by Birsoys and Shens groups 11,12 , does not undergo post-translational regulation via the GSH-sensing stability loop that controls SLC25A39 protein levels

[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Baker DA, McFarland K, Lake RW, et al

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Assuming a sequential reaction, where the enzyme, GPX, must bind to both substrates, ROS and GSH, for the reaction producing GSSG to occur and letting ROS and GSH to be the leading and following substrates, respectively, is the the reaction rate for GSSG

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Although the altered redox balance in cancer contributes to tumor progression, it simultaneously presents a significant therapeutic target