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A second Phase I study in adults with diabetic kidney disease reported a D+Q dependent clearance of senescent adipose and skin cells and reduced SASP within 11 days of treatment (106)

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Together with IL-12 and IL-18 or transforming tumor necrosis growth factor (TGF)-, IL-6, and IL-23, TNF- induces the differentiation of nave CD4+ T cells into pro-inflammatory T helper cells of type 1 (T H 1) and type 17 (T H 17), respectively [6,12,13]

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