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However, studies have suggested that the reduction of Gln levels may disturb the Glu/Gln cycle between astrocytes and neurons, thus affecting Glu concentrations in the brain and potentially altering glutamatergic neurotransmission [100, 101]
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"Worse, current pharmacological treatments are effective for only about 50 percent of the people for whom they're prescribed
The trial data (STEP 4) supports continued therapeutic dosing
