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To enhance the direct killing effect, targeted strategies that promote the accumulation of NK cells at the tumor site have been proposed

RNA analysis Tissue samples were crushed on dry ice and homogenized using a bead Mill (VWR)

Cystine starvation leads to GSH depletion and also induces glutamate accumulation, which inactivates GPX4 and ultimately leads to ferroptosis [52]

[DOI] [PubMed] [Google Scholar] Kuhn S, Zipfel PF

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Chronic and recurring infections, altered adipose tissue metabolism, intestinal dysbiosis, increased synthesis and impaired clearance of pro-inflammatory cytokines, oxidative stress, and acidosis are some of the variables that lead to chronic inflammatory status in CKD