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Nuclear nicotinamide adenine dinucleotide deficiency by Nmnat1 deletion impaired hepatic insulin signaling, mitochondrial function, and hepatokine expression in mice fed a high-fat diet

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On top of the role of NAD + as a direct substrate for the TCA and ETC, much of the influence of NAD + on mitochondrial homeostasis is through the NAD + -consuming enzymes sirtuins