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In a 4-week, open-label pilot study in 23 treatment-seeking cocaine-dependent subjects, NAC at doses of 1.2, 2.4, and 3.6 g/day improved retention rates and was well tolerated [127]

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& Jannetta, P

Although most intracellular iron is tightly bound to proteins or incorporated into proteins as a cofactor or for storage, some free iron resides in the cytoplasm and intracellular organelles (such as lysosomes), constituting redox-active-dependent iron pools that regulate programmed cell death, including ferroptosis ( As the most powerful antioxidant, it is worth noting that the anti-ferroptosis mechanism of AST protecting DED has not been investigated in vitro and in vivo

It has also been found to protect the liver from damage

, Jofre, F