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Sodium butyrate abrogates the growth and pathogenesis of Mycobacterium bovis via regulation of cathelicidin (LL37) expression and NF-B signaling

Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome

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doi: 10.1038/aja.2010.76

The intestinal mucosal epithelium consists of a single layer of columnar epithelial cells, including absorptive enterocytes responsible for nutrient uptake, goblet cells that secrete the gel-forming glycoprotein mucin 2 (MUC2) as the primary constituent of the mucus layer, and Paneth cells residing in the crypt bases which secrete antimicrobial peptides (e.g., defensins, cryptdins) and lysozyme contributing to innate immune defense, and enteroendocrine cells that release hormones regulating intestinal function [10]

NLRP3 inflammasome inhibitor MCC950 can reduce the damage of pancreatic and intestinal barrier function in mice with acute pancreatitis