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Chem Res Toxicol 21:14771483 Liao S, Ewing NP, Boucher B, Materne O, Brummel CL (2012) High-throughput screening for glutathione conjugates using stable-isotope labeling and negative electrospray ionization precursor-ion mass spectrometry

[129] [130] Later steps, especially the incorporation of the additional methyl groups of its structure, were investigated using 13 C methyl-labelled S-adenosyl methionine

Each sample was resuspended in 20 l of LC/MS grade water and 10 l per sample was injected into a 5500 QTRAP, a hybrid triple quadrupole/linear ion trap mass spectrometer, using a quantitative polar metabolomics profiling platform with selected reaction monitoring (SRM) that covers all major metabolic pathways

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Pain, redness, or swelling at the place of injection are the most frequently reported side effects