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Cell 128 , 635638 (2007)

Current Bioinformatics 7 , 8795, doi:10.2174/157489312799304495 (2012)

Rubins H, Robins S, Collins D, Fye C, Anderson J, Elam M, Faas F, Linares E, Schaefer E, Schectman G, Wilt T, Wittes J

[oai_citation:0PMC]( Key pointMost findings below come from in vitro or non-human in vivo experiments

One reason for this is that the application of cosmetic ingredients is much simpler than that of pharmaceuticals, which require costly clinical trials

In addition, changes in histone marks, such as increased acetylation or decreased methylation, lead to chromatin relaxation, thereby increasing DNA accessibility and susceptibility to damage from ROS and IR (112, 113)