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The axonopathy in the dorsal and lateral columns can be visualized using magnetization transfer imaging in severely affected patients with AMN (Fig 1B and Ref

Consanguinity and the founder effect have a significant impact on the incidence and severity of ABC transporter-associated cholestasis, as 85%90% of affected individuals have parental consanguinity

4 Multiple triggers have been reported in the literature, including physical stressors, infections, and medications

Regulation and removal of hydrogen peroxide prevents the formation of the highly reactive and damaging hydroxyl radical, which can be formed by reaction of hydrogen peroxide with Fe 2+ (Fenton reaction)

TEM is a mechanism by which endothelium may play a role in COPD and therefore may be important in the development of inflammation and in the pathogenesis of COPD

Continuous values are presented as means standard deviation if normally distributed